Chicago lost 3-1 to the Los Angeles Kings on Saturday to finish 0-5-0-1 on its six game road trip, and extend its winless streak to 11 games (0-7-1-3).
It was the sixth time the Blackhawks have been swept on a road trip of six or more games in their 78-year history, and the first time since going 0-7 from Nov. 23-Dec. 10, 1988.
"Losing wears on you," Chicago center Scott Nichol said. "But it's up to us. We have to dig down deep and turn it around."
The Blackhawks have scored no more than three goals in any of their first 25 games -- the second-longest streak in the franchise history.
Chicago's slide has coincided with an injury to goaltender Jocelyn Thibault. Since Thibault was lost to a hip injury, Craig Anderson is 0-5 and Michael Leighton is 0-5-1.
"It's a team game and it takes all 20 guys to get a win," Anderson said. "All I can do is play my best every night and maybe steal a win. It's tough, but it's something I've got to work through."
The 11-game winless streak is Chicago's longest since finishing the 2000-01 season 0-10-1. The Blackhawks haven't gone without a victory in 12 consecutive games since an 0-10-3 stretch from March 29-April 23, 1995.
Chicago will be looking to end its skid against a Buffalo team it's 0-2-1 against since a 3-1 home win on Oct. 28, 2000.
The Sabres, however, have lost their last four road games, including a 4-1 defeat to the Nashville Predators on Saturday that ended their two-game winning streak.
"It wasn't our best effort," Buffalo captain Chris Drury said. "They were moving their feet pretty good. We couldn't keep up."