Rookie defenseman Adam Almquist scored both power-play goals in a 5:40 span of the second period, beating Tomas Vokoun with slap shots from the blue line. Pavel Datsyuk and Tomas Tatar also had goals for the Red Wings.
"I got a little bit lucky at first," Almquist said. "The puck was popping out to me and I could just go ahead a rip it off. Luckily it went in. The second one, I got a really good pass from Samuelsson, shot it and it went in. I got lucky there too."
Pittsburgh outshot Detroit 24-19 but failed to convert on three first-period power plays and lost for the second time in as many nights.
"We still made some mistakes. It's the preseason, you're going to do that," captain Sidney Crosby said. "But I think we got better. We've got some games here to get sharper."